Deoxysugars as antituberculars and alpha-mannosidase inhibitors.
نویسندگان
چکیده
A promising modified sugar molecule was identified which was active against multidrug-resistant (MDR) strains of Mycobacterium tuberculosis, suggesting involvement of a new target. The compound was demonstrated to be bactericidal, inhibited the growth of M. tuberculosis in mice, and targeted alpha-mannosidase as a competitive inhibitor with a Ki value of 353.9 μM.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 58 6 شماره
صفحات -
تاریخ انتشار 2014